Publicaciones - Neurobiología del estrés y la adicción

2020

Maes T, Mascaró C, Rotllant D, Lufino MMP, Estiarte A, Guibourt N, Cavalcanti F, Griñan-Ferré C, Pallàs M, Nadal R, Armario A, Ferrer I, Ortega A, Valls N, Fyfe M, Martinell M, Castro-Palomino JC, Buesa-Arjol C. Modulation of KDM1A with vafidemstat rescues memory deficit and behavioral alterations. PLoS ONE 2020, 15(5):e0233468.

Domingo-Rodriguez L, Ruiz de Azua I, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B, Martín-García E, Maldonado R. A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nat Commun. 2020, 11(1):782.

2019

Melia CS, Soria V, Salvat-Pujol N, Cabezas Á, Nadal R, Urretavizcaya M, Gutiérrez-Zotes A, Monreal JA, Crespo JM, Alonso P, Vilella E, Palao D, Menchón JM, Labad J. Sex-specific association between the cortisol awakening response and obsessive-compulsive symptoms in healthy individuals. Biol Sex Differ. 2019, 10(1):55.

Kreutzmann JC, Khalil R, Köhler JC, Mayer D, Florido A, Nadal R, Andero R, Fendt M. Neuropeptide-S-Receptor Deficiency Affects Sex-Specific Modulation of Safety Learning by Pre-Exposure to Electric Stimuli. Genes Brain Behav. 2019, Epub ahead of print.

Tost M, Monreal JA, Armario A, Barbero JD, Cobo J, García-Rizo C, Bioque M, Usall J, Huerta-Ramos E, Soria V; PNECAT Group, Labad J. Targeting Hormones for Improving Cognition in Major Mood Disorders and Schizophrenia: Thyroid Hormones and Prolactin. Clin Drug Investig. 2019, Epub ahead of print.

Labad J, Soria V, Armario A, Nadal R, Monreal JA, Palao D. Levothyroxine treatment for persistent cognitive symptoms in major depression. Rev Psiquiatr Salud Ment. 2019, 12(3):199-200.

Tortella-Feliu M, Fullana MA, Pérez-Vigil A, Torres X, Chamorro J, Littarelli SA, Solanes A, Ramella-Cravaro V, Vilar A, González-Parra JA, Andero R, Reichenberg PA, Mataix-Cols PD, Vieta E, Fusar-Poli P, Ioannidis PJPA, Stein PMB, Radua J, Fernández de la Cruz L. Risk factors for posttraumatic stress disorder: An umbrella review of systematic reviews and meta-analyses. Neurosci Biobehav Rev. 2019, 107:154-165.

Velasco ER, Florido A, Milad MR, Andero R. Sex differences in fear extinction. Neurosci Biobehav Rev. 2019, 103:81-108.

Lori A, Maddox SA, Sharma S, Andero R, Ressler KJ, Smith AK. Dynamic Patterns of Threat-Associated Gene Expression in the Amygdala and Blood. Front Psychiatry. 2019; 9:778.

Sanchís-Ollé M, Fuentes S, Úbeda-Contreras J, Lalanza JF, Ramos-Prats A, Armario A, Nadal R. Controllability affects endocrine response of adolescent male rats to stress as well as impulsivity and behavioral flexibility during adulthood. Sci Rep. 2019, 9(1):3180.

Saravia R, Ten-Blanco M, Julià-Hernández M, Gagliano H, Andero R, Armario A, Maldonado R, Berrendero F. Concomitant THC and stress adolescent exposure induces impaired fear extinction and related neurobiological changes in adulthood. Neuropharmacology. 2019, 144:345-357.

2018

Labad J, Armario A, Nadal R, Solé M, Gutiérrez-Zotes A, Montalvo I, Moreno-Samaniego L, Martorell L, Sánchez-Gistau V, Vilella E. Clinical correlates of hypothalamic-pituitary-adrenal axis measures in individuals at risk for psychosis and with first-episode psychosis. Psychiatry Res. 2018, 265:284-291.

Marín-Blasco I, Muñoz-Abellán C, Andero R, Nadal R, Armario A. Neuronal activation after prolonged immobilization: do the same or different neurons respond to a novel stressor? Cereb Cortex. 2018, 28(4):1233-1244.

Fuentes S, Daviu N, Gagliano H, Belda X, Armario A, Nadal R. Early life stress in rats sex-dependently affects remote endocrine rather than behavioral consequences of adult exposure to contextual fear conditioning. Horm Behav. 2018, 103:7-18.

Úbeda-Contreras J, Marín-Blasco I, Nadal R, Armario A. Brain c-fos expression patterns induced by emotional stressors differing in nature and intensity. Brain Struct Funct. 2018, 223(5):2213-2227.

Flores A, Fullana MA, Soriano-Mas C, Andero R. Lost in translation: how to upgrade fear memory research. Mol Psychiatry. 2018, 23(11):2122-2132.

Fuentes S, Carrasco J, Hatto A, Navarro J, Armario A, Monsonet M, Ortiz J, Nadal R. Sex-dependent impact of early-life stress and adult immobilization in the attribution of incentive salience in rats. PLoS One. 2018, 13(1):e0190044.

Montalvo I, Nadal R, Armario A, Gutiérrez-Zotes A, Creus M, Cabezas A, Solé M, Algora MJ, Sánchez-Gistau V, Vilella E, Labad J. Sex differences in the relationship between prolactin levels and impaired processing speed in early psychosis. Aust N Z J Psychiatry, 2018, 52(6):585-595.

Wingo AP, Velasco E, Florido A, Lori A, Choi DC, Jovanovic T, Ressler KJ, Andero R. Expression of the PPM1F gene is regulated by stress and associated with anxiety and depression. Biol Psychiatry, 2018, 83(3):284-295.

2017

Gutiérrez-Sacristán A, Bravo A, Portero-Tresserra M, Valverde O, Armario A, Blanco-Gandía MC, Farré A, Fernández-Ibarrondo L, Fonseca F, Giraldo J, Leis A, Mané A, Mayer MA, Montagud-Romero S, Nadal R, Ortiz J, Pavon FJ, Perez EJ, Rodríguez-Arias M, Serrano A, Torrens M, Warnault V, Sanz F, Furlong LI. Text mining and expert curation to develop a database on psychiatric diseases and their genes. Database, 2017, Jan 1:2017.

Gagliano H, Ortega-Sanchez JA, Nadal R, Armario A. Psychostimulants and forced swim stress interaction: how activation of the hypothalamic-pituitary-adrenal axis and stress-induced hyperglycemia are affected. Psychopharmacology, 2017, 234(19):2859-2869.

Garzon-Rey JM, Arza A, de-la-Camara C, Lobo A, Armario A, Aguilo J. An approach to an acute emotional stress reference scale. Rev Neurol. 2017, 64(12):529-537.

Galatzer-Levy IR, Andero R, Sawamura T, Jovanovic T, Papini S, Ressler KJ, Norrholm SD. A cross species study of heterogeneity in fear extinction learningin relation to FKBP5 variation and expression: Implications for the acute treatment of posttraumatic stress disorder. Neuropharmacology. 2017, 116:188-195.

Corominas-Roso M, Armario A, Palomar G, Corrales M, Carrasco J, Richarte V, Ferrer R, Casas M, Ramos JA. IL-6 and TFN-α in unmedicated adults with ADHD: relationship to cortisol awakening response. Psychoneuroendocrinology. 2017, 79:67-73.

Sanchís-Ollé M, Ortega-Sánchez JA, Belda X, Gagliano H, Nadal R, Armario A. Lithium-induced malaise does not interfere with adaptation of the hypothalamic-pituitary-adrenal axis to stress. Prog Neuropsychopharmacol Biol Psychiatry. 2017, 75:77-83.

2016

Andero R, Daniel S, Guo JD, Bruner RC, Seth S, Marvar PJ, Rainnie D, Ressler KJ. Amygdala-Dependent Molecular Mechanisms of the Tac2 Pathway in Fear Learning. Neuropsychopharmacology. 2016, 41(11):2714-22.

Belda X, Nadal R, Armario A. Critical features of acute stress-induced cross-sensitization identified through the hypothalamic-pituitary-adrenal axis output. Sci Rep. 2016, 6:31244.

Calleja-Conde J, Echeverry-Alzate V, Giné E, Bühler KM, Nadal R, Maldonado R, Rodríguez de Fonseca F, Gual A, López-Moreno JA. Nalmefene is effective at reducing alcohol seeking, treating alcohol-cocaine interactions and reducing alcohol-induced histone deacetylases gene expression in blood. Br J Pharmacol. 2016, 173(16):2490-505.

Sanz-García A, Knafo S, Pereda-Pérez I, Esteban JA, Venero C, Armario A. Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity. Hippocampus. 2016, 26(9):1179-88.

Souza Queiroz J, Marín Blasco I, Gagliano H, Daviu N, Gómez Román A, Belda X, Carrasco J, Rocha MC, Palermo Neto J, Armario A. Chlorella vulgaris reduces the impact of stress on hypothalamic-pituitary-adrenal axis and brain c-fos expression. Psychoneuroendocrinology. 2016, 65:1-8.

Fodor A, Kovács KB, Balázsfi D, Klausz B, Pintér O, Demeter K, Daviu N, Rabasa C, Rotllant D, Nadal R, Zelena D. Depressive- and anxiety-like behaviors and stress-related neuronal activation in vasopressin-deficient female Brattleboro rats. Physiol Behav. 2016, 158:100-11.

Gómez-Román A, Ortega-Sánchez JA, Rotllant D, Gagliano H, Belda X, Delgado-Morales R, Marín-Blasco I, Nadal R, Armario A. The neuroendocrine response to stress under the effect of drugs: negative synergy between amphetamine and stressors. Psychoneuroendocrinology. 2016, 63:94-101.

Sawamura T, Klengel T, Armario A, Jovanovic T, Norrholm SD, Ressler KJ, Andero R. Dexamethasone treatment leads to enhanced fear extinction and dynamic Fkbp5 regulation in amygdala. Neuropsychopharmacology. 2016, 41:832-46.

Gracia-Rubio I, Moscoso-Castro M, Pozo OJ, Marcos J, Nadal R, Valverde O. Maternal separation induces neuroinflammation and long-lasting emotional alterations in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2016, 65:104-17.

2015

Armario A. Studying Chronic Stress in Animals: Purposes, Models and Consequences. In: Rusell J, Shipston M, editors. Neuroendocrinology of Stress, 1st ed. 2015, UK, Chichester: John Wiley & Sons, Ltd, pp 143-167.

Armario A, Sanz-García A, Andero R. How a traumatic stressor impact on spatial memory and the hippocampus: Possible protective effect of a TrkB agonist. Psychoneuroendocrinology. 2015, 61:19.

Lalanza JF, Sanchez-Roige S, Cigarroa I, Gagliano H, Fuentes S, Armario A, Capdevila L, Escorihuela RM. Long-term moderate treadmill exercise promotes stress-coping strategies in male and female rats. Sci Rep. 2015, 5:16166.

Young MB, Andero R, Ressler KJ, Howell LL. 3,4-Methylenedioxymethamphetamine facilitates fear extinction learning. Transl Psychiatry. 2015, 15;5:e634.

Aguiló J, Ferrer-Salvans P, García-Rozo A, Armario A, Corbí Á, Cambra FJ, Bailón R, González-Marcos A, Caja G, Aguiló S, López-Antón R, Arza-Valdés A, Garzón-Rey JM. Project ES3: attempting to quantify and measure the level of stress. Rev Neurol. 2015, 61(9):405-15.

Rosas-Vidal LE, Rodriguez-Romaguera J, Do-Monte FH, Andero R. Targeting the reconsolidation of extinction memories: a novel potential strategy to treat anxiety disorders. Mol Psychiatry. 2015, 20(11):1264-5.

Belda X, Fuentes S, Daviu N, Nadal R, Armario A. Stress-induced sensitization: the hypothalamic-pituitary-adrenal axis and beyond. Stress. 2015, 18:269-79.

Andero R. Nociceptin and the nociceptin receptor in learning and memory. Prog Neuropsychopharmacol Biol Psychiatry. 2015, 1;62:45-50.

López-Moreno JA, Marcos M, Calleja-Conde J, Echeverry-Alzate V, Bühler K, Costa-Alba P, Bernardo E, Laso FJ, Rodríguez de Fonseca F, Nadal R, Viveros MP, Maldonado R, Giné E. Histone deacetylase gene expression following binge alcohol consumption in rats and humans. Alcohol Clin Exp Res. 2015, 39:1939-50.

Rabasa C, Pastor-Ciurana J, Delgado-Morales R, Gómez-Román A, Carrasco J, Gagliano H, García-Gutiérrez MS, Manzanares J, Armario A. Evidence against a critical role of CB1 receptors in adaptation of the hypothalamic-pituitary-adrenal axis and other consequences of daily repeated stress. Eur Neuropsychopharmacol. 2015, 25:1248-59.

Rabasa C, Gagliano H, Pastor-Ciurana J, Fuentes S, Nadal R, Armario A. Adaptation of the hypothalamus-pituitary-adrenal axis to daily repeated stress does not follow the rules of habituation: a new perspective. Neurosci Biobehav Rev. 2015, 56:35-49.

Scorrano F, Carrasco J, Pastor-Ciurana J, Belda X, Rami-Bastante A, Bacci ML, Armario A. Validation of the long-term assessment of hypothalamic-pituitary-adrenal activity in rats using hair corticosterone as a biomarker. FASEB J. 2015, 29(3):859-67.

2014

Dias BG, Goodman JV, Ahluwalia R, Easton AE, Andero R, Ressler KJ. Amygdala-dependent fear memory consolidation via miR-34a and Notch signaling. Neuron. 2014, 20;83(4):906-18.

Gagliano H, Nadal R, Armario A. Sex differences in the long-lasting effects of a single exposure to immobilization stress in rats. Horm Behav. 2014, 66(5):793-801.

Andero R, Dias BG, Ressler KJ. A role for Tac2, NkB, and Nk3 receptor in normal and dysregulated fear memory consolidation. Neuron. 2014, 83(2):444-54.

Daviu N, Andero R, Armario A, Nadal R. Sex differences in the behavioural and hypothalamic-pituitary-adrenal response to contextual fear conditioning in rats. Horm Behav. 2014, 66(5):713-23.

Andero R, Choi DC, Ressler KJ. BDNF-TrkB receptor regulation of distributed adult neural plasticity, memory formation, and psychiatric disorders. Prog Mol Biol Transl Sci. 2014, 122:169-92.

Fuentes S, Carrasco J, Armario A, Nadal R. Behavioral and neuroendocrine consequences of juvenile stress combined with adult immobilization in male rats. Horm Behav. 2014, 66(3):475-86.

Daviu N, Rabasa C, Nadal R, Armario A. Comparison of the effects of single and daily repeated immobilization stress on resting activity and heterotypic sensitization of the hypothalamic-pituitary-adrenal axis. Stress. 2014, 17(2):176-85.

Fuentes S, Daviu N, Garrido P, Gagliano H, Zelena D, Monasterio N, Armario A, Nadal R. Sex-dependent effects of an early life treatment in rats that increases maternal care: vulnerability or resilience? Front Behavioral Neurosci. 2014, 8:56.

Pastor-Ciurana J, Rabasa C, Ortega-Sánchez JA, Sanchís M, Gabriel-Salazar M, Ginesta M, Belda X, Daviu N, Nadal R, Armario A. Prior exposure to repeated immobilization or chronic unpredictable stress protects from some negative sequels of an acute immobilization Behav Brain Res. 2014, 265:155-62.

Echeverry-Alzate V, Giné E, Bühler K, Olmos P, Gorriti MA, Nadal R, Rodriguez de Fonseca F, López-Moreno JA. The Effects of Topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex. British J Pharmacol. 2014, 171(12):3023-36.

Feliu-Soler A, Pascual JC, Borràs X, Portella MJ, Martín-Blanco A, Armario A, Alvarez E, Pérez V, Soler J. Effects of dialectical behaviour therapy-mindfulness training on emotional reactivity in borderline personality disorder: preliminary results. Clin Psychol Psychother. 2014, 21(4):363-70.

Gagliano H, Delgado-Morales R, Sanz-Garcia A, Armario A. High doses of the histone deacetylase inhibitor sodium butyrate trigger a stress-like response. Neuropharmacology. 2014, 79:75-82.

2013

Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ. Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD. Sci Transl Med. 2013, 5(188):188ra73.

Armario A, Nadal R. Individual differences and the characterization of animal models of psychopathology: a strong challenge and a good opportunity. Frontiers in Pharmacol. 2013, 4, A137.

Rabasa C, Delgado-Morales R, Gómez-Román A, Nadal R, Armario A. Adaptation of the pituitary-adrenal axis to daily repeated forced swim exposure in rats is dependent on the temperature of water. Stress. 2013, 16(6):698-705.

Rotllant D, Pastor-Ciurana J, Armario A. Stress-induced brain histone H3 phosphorylation: contribution of the intensity of stressors and length of exposure. J Neurochem. 2013, 125(4):599-609.

Armario A, Nadal R. Searching for biological markers of personality: are there neuroendocrine markers of anxiety?. In: Durbano F (Ed.) New insights into anxiety disorders. InTech. 2013, 71-104.

Feliu-Soler A, Pascual JC, Soler J, Pérez V, Armario A, Carrasco J, Sanz A, Villamarín F, Borràs X. Emotional responses to a negative emotion induction procedure in Borderline Personality Disorder. Internat J Clinic Health Psychol. 2013, 13:9-17.

2012

Daviu N, Delgado‐Morales R, Nadal R, Armario A. Not all stressors are equal: behavioural and endocrine evidence for development of contextual fear conditioning after a single session of footshocks but not of immobilization. Front Behavioral Neurosci. 2012, 6:69.

Andero R, Ressler KJ. Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes Brain Behav. 2012, 11(5):503-12.

Fodor A, Klausz B, Pintér O, Daviu N, Rabasa C, Rotllant D, Balazsfi D, Kovacs KB, Nadal R, Zelena D. Maternal neglect with reduced depressive-like behavior and blunted c-fos activation in Brattleboro mothers, the role of central vasopressin. Horm Behav. 2012, 62(4):539-51.

Belda X, Daviu N, Nadal R, Armario A. Acute-stress induced sensitization of the pituitary-adrenal response to heterotypic stressors: independence of glucocorticoid release and activation of CRH1 receptors. Horm Behav. 2012, 62(4):515-24.

Lalanza JF, Sanchez-Roige S, Gagliano H, Fuentes S, Bayod S, Camins A, Pallàs M, Armario A, Escorihuela RM. Physiological and behavioural consequences of long-term moderate treadmill exercise. Psychoneuroendocrinology. 2012, 37(11):1745-54.

Armario A, Daviu N, Muñoz-Abellán C, Rabasa C, Fuentes S, Belda X, Gagliano H, Nadal R. What can we know from pituitary-adrenal hormones about the nature and consequences of exposure to emotional stressors? Cell Mol Neurobiol. 2012, 32(5):749-58.

Delgado-Morales R, del Río E, Gómez-Román A, Bisagno V, Nadal R, de Felipe C, Armario A. Adrenocortical and behavioural response to chronic restraint stress in neurokinin-1 receptor knockout mice. Physiol Behav. 2012, 105(3):669-75.

Andero R, Daviu N, Escorihuela RM, Nadal R, Armario A. 7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus. 2012, 22(3):399-408.

Rotllant D, Armario A. Brain pattern of histone H3 phosphorylation after acute amphetamine administration: Its relationship to brain c-fos induction is strongly dependent on the particular brain area. Neuropharmacology. 2012, 62(2):1073-81.

López-Gallardo M, López-Rodríguez AB, Llorente-Berzal Á, Rotllant D, Mackie K,Armario A, Nadal R, Viveros MP. Maternal deprivation and adolescent cannabinoid exposure impact hippocampal astrocytes, CB1 receptors and brain-derived neurotrophic factor in a sexually dimorphic fashion. Neuroscience. 2012, 204:90-103.

Ribeiro Do Couto B, Daza-Losada M, Rodríguez-Arias M, Nadal R, Guerri C, Summavielle T, Miñarro J, Aguilar MA. Adolescent pre-exposure to ethanol and 3,4-methylenedioxymethylamphetamine (MDMA) increases conditioned rewarding ffects of MDMA and drug-induced reinstatement. Addict Biol. 2012, 17(3):588-600.

Hoffmann HM, Nadal R, Vignes M, Ortiz J. Chronic cocaine self-administration modulates ERK1/2 and CREB responses to dopamine receptor agonists in striatal slices. Addict Biol. 2012, 17(3):565-75.

2011

Muñoz-Abellán C, Rabasa C, Daviu N, Nadal R, Armario A. Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence? PLoS One. 2011, 6(6):e21426.

Llorente-Berzal A, Fuentes S, Gagliano H, López-Gallardo M, Armario A, Viveros MP, Nadal R. Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour. Addict Biol. 2011, 16(4):624-37.

Alobid I, de Pablo J, Mullol J, Centellas S, Parramon G, Carrasco J, Armario A, Bernal-Sprekelsen M. Increased cardiovascular and anxiety outcomes but not endocrine biomarkers of stress during performance of endoscopic sinus surgery: a pilot study among novice surgeons. Arch Otolaryngol Head Neck Surg. 2011, 137(5):487-92.

Do Couto BR, Rodríguez-Arias M, Fuentes S, Gagliano H, Armario A, Miñarro J, Aguilar MA. Adolescent pre-exposure to ethanol or MDMA prolongs the conditioned rewarding effects of MDMA. Physiol Behav. 2011, 103(5):585-93.

Rabasa C, Muñoz-Abellán C, Daviu N, Nadal R, Armario A. Repeated exposure to immobilization or two different footshock intensities reveals differential adaptation of the hypothalamic-pituitary-adrenal axis. Physiol Behav. 2011, 103(2):125-33.

Rabasa C, Delgado-Morales R, Muñoz-Abellán C, Nadal R, Armario A. Adaptation of the hypothalamic-pituitary-adrenal axis and glucose to repeated immobilization or restraint stress is not influenced by associative signals. Behav Brain Res. 2011, 217(1):232-9.

Andero R, Heldt SA, Ye K, Liu X, Armario A, Ressler KJ. Effect of 7,8-Dihydroxyflavone, a Small-Molecule TrkB Agonist, on Emotional Learning. Am J Psychiatry. 2011, 168(2):163-72.

2010

Jang SW, Liu X, Chan CB, France SA, Sayeed I, Tang W, Lin X, Xiao G, Andero R, Chang Q, Ressler KJ, Ye K. Deoxygedunin, a natural product with potent neurotrophic activity in mice. PLoS One. 2010, 13;5(7):e11528.

Ons S, Rotllant D, Marín-Blasco IJ, Armario A. Immediate-early gene response to repeated immobilization: Fos protein and arc mRNA levels appear to be less sensitive than c-fos mRNA to adaptation. Eur J Neurosci. 2010, 31(11):2043-52.

Armario A. Activation of the hypothalamic-pituitary-adrenal axis by addictive drugs: different pathways, common outcome. Trends Pharmacol Sci. 2010, 31(7):318-25.

Daviu N, Fuentes S, Nadal R, Armario A. A single footshock causes long-lasting hypoactivity in unknown environments that is dependent on the development of contextual fear conditioning. Neurobiol Learn Mem. 2010, 94(2):183-90.

Rotllant D, Márquez C, Nadal R, Armario A. The brain pattern of c-fos induction by two doses of amphetamine suggests different brain processing pathways and minor contribution of behavioural traits. Neuroscience. 2010, 168(3):691-705.

Muñoz-Abellán C, Armario A, Nadal R. Do odors from different cats induce equivalent unconditioned and conditioned responses in rats? Physiol Behav. 2010, 99(3):388-94.

Amador-Arjona A, Delgado-Morales R, Belda X, Gagliano H, Gallego X, Keck ME, Armario A, Dierssen M. Susceptibility to stress in transgenic mice overexpressing TrkC, a model of panic disorder. J Psychiatr Res. 2010, 44(3):157-67.

2009

Gagliano H, Andero R, Armario A, Nadal R. Repeated amphetamine administration in rats revealed consistency across days and a complete dissociation between locomotor and hypothalamic-pituitary-adrenal axis effects of the drug. Psychopharmacology. 2009, 207(3):447-59.

Muñoz-Abellán C, Daviu N, Rabasa C, Nadal R, Armario A. Cat odor causes long-lasting contextual fear conditioning and increased pituitary-adrenal activation, without modifying anxiety. Horm Behav. 2009, 56(4):465-71.

Belda X, Armario A. Dopamine D1 and D2 dopamine receptors regulate immobilization stress-induced activation of the hypothalamus-pituitary-adrenal axis. Psychopharmacology. 2009, 206(3):355-65.

Peña Y, Prunell M, Rotllant D, Armario A, Escorihuela RM. Enduring effects of environmental enrichment from weaning to adulthood on pituitary-adrenal function, pre-pulse inhibition and learning in male and female rats. Psychoneuroendocrinology. 2009, 34(9):1390-404.

2008

Belda X, Rotllant D, Fuentes S, Delgado R, Nadal R, Armario A. Exposure to severe stressors causes long-lasting dysregulation of resting and stress-induced activation of the hypothalamic-pituitary-adrenal axis. Ann N Y Acad Sci. 2008, 1148:165-73.

Belda X, Fuentes S, Nadal R, Armario A. A single exposure to immobilization causes long-lasting pituitary-adrenal and behavioral sensitization to mild stressors. Horm Behav. 2008, 54(5):654-61.

Muñoz-Abellán C, Andero R, Nadal R, Armario A. Marked dissociation between hypothalamic-pituitary-adrenal activation and long-term behavioral effects in rats exposed to immobilization or cat odor. Psychoneuroendocrinology. 2008, 33(8):1139-50.

Armario A, Escorihuela RM, Nadal R. Long-term neuroendocrine and behavioural effects of a single exposure to stress in adult animals. Neurosci Biobehav Rev. 2008, 32(6):1121-35.

Carrasco J, Márquez C, Nadal R, Tobeña A, Fernández-Teruel A, Armario A. Characterization of central and peripheral components of the hypothalamus-pituitary-adrenal axis in the inbred Roman rat strains. Psychoneuroendocrinology. 2008, 33(4):437-45.

Gagliano H, Fuentes S, Nadal R, Armario A. Previous exposure to immobilisation and repeated exposure to a novel environment demonstrate a marked dissociation between behavioral and pituitary-adrenal responses. Behav Brain Res. 2008, 187(2):239-45.

2007

Dimitsantos E, Escorihuela RM, Fuentes S, Armario A, Nadal R. Litter size affects emotionality in adult male rats. Physiol Behav. 2007, 92(4):708-16.

Andero R, Torras-Garcia M, Quiroz-Padilla MF, Costa-Miserachs D, Coll-Andreu M. Electrical stimulation of the pedunculopontine tegmental nucleus in freely moving awake rats: time- and site-specific effects on two-way active avoidance conditioning. Neurobiol Learn Mem. 2007, 87(4):510-21.

Rotllant D, Nadal R, Armario A. Differential effects of stress and amphetamine administration on Fos-like protein expression in corticotrophin releasing factor-neurons of the rat brain. Dev Neurobiol. 2007, 67(6):702-14.

Trnecková L, Rotllant D, Klenerová V, Hynie S, Armario A. Dynamics of immediate early gene and neuropeptide gene response to prolonged immobilization stress: evidence against a critical role of the termination of exposure to the stressor. J Neurochem. 2007, 100(4):905-14.

2006

Armario A. The hypothalamic-pituitary-adrenal axis: what can it tell us about stressors? CNS Neurol Disord Drug Targets. 2006, 5(5):485-501.

Armario A. The contribution of immediate early genes to the understanding of brain processing of stressors. IN: Immediate early genes in sensory processing, cognitive performance and neurological disorders; R Pinaud and L Tremere Eds, Springer Science+Business Media, 2006, pp. 199-221.

Peña Y, Prunell M, Dimitsantos V, Nadal R, Escorihuela RM. Environmental enrichment effects in social investigation in rats are gender dependent. Behav Brain Res. 2006, 174(1):181-7.

Vallès A, Martí O, Armario A. Long-term effects of a single exposure to immobilization: a c-fos mRNA study of the response to the homotypic stressor in the rat brain. J Neurobiol. 2006, 66(6):591-602.

Ribeiro Do Couto B, Aguilar MA, Manzanedo C, Rodríguez-Arias M, Armario A, Miñarro J. Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice. Psychopharmacology. 2006, 185(4):459-70.

Trnecková L, Armario A, Hynie S, Sída P, Klenerová V. Differences in the brain expression of c-fos mRNA after restraint stress in Lewis compared to Sprague-Dawley rats. Brain Res. 2006, 1077(1):7-15.

Márquez C, Nadal R, Armario A. Influence of reactivity to novelty and anxiety on hypothalamic-pituitary-adrenal and prolactin responses to two different novel environments in adult male rats. Behav Brain Res. 2006, 168(1):13-22.

Nadal R, Escorihuela RM, Armario A .The elevated plus-maze test of anxiety: methodological considerations. In: Anderson MJ (Ed.) Tasks and techniques: a sampling of the methodologies for the investigation of animal learning, behavior and cognition. Nova Science Publishers, NY, 2006, 25-37.

2005

Nadal R, Rotllant D, Márquez C, Armario A. Perseverance of exploration in novel environments predicts morphine place conditioning in rats. Behav Brain Res. 2005, 165(1):72-9.

Vallès A, Martí O, Armario A. Mapping the areas sensitive to long-term endotoxin tolerance in the rat brain: a c-fos mRNA study. J Neurochem. 2005, 93(5):1177-88.

Belda X, Ons S, Carrasco J, Armario A. The effects of chronic food restriction on hypothalamic-pituitary-adrenal activity depend on morning versus evening availability of food. Pharmacol Biochem Behav. 2005, 81(1):41-6.

Rotllant D, Armario A. A single dose of metyrapone caused long-term dysregulation of the hypothalamic-pituitary-adrenal axis in the rat. Neuroscience. 2005, 130(2):427-34.

Márquez C, Nadal R, Armario A. Responsiveness of the hypothalamic-pituitary-adrenal axis to different novel environments is a consistent individual trait in adult male outbred rats. Psychoneuroendocrinology. 2005, 30(2):179-87.

2004

Armario A, Vallès A, Dal-Zotto S, Márquez C, Belda X. A single exposure to severe stressors causes long-term desensitisation of the physiological response to the homotypic stressor. Stress. 2004, 7(3):157-72.

Belda X, Márquez C, Armario A. Long-term effects of a single exposure to stress in adult rats on behavior and hypothalamic-pituitary-adrenal responsiveness: comparison of two outbred rat strains. Behav Brain Res. 2004, 154(2):399-408.

Armario A, Martí O, Vallès A, Dal-Zotto S, Ons S. Long-term effects of a single exposure to immobilization on the hypothalamic-pituitary-adrenal axis: neurobiologic mechanisms. Ann N Y Acad Sci. 2004, 1018:162-72.

Dal-Zotto S, Martí O, Delgado R, Armario A. Potentiation of glucocorticoid release does not modify the long-term effects of a single exposure to immobilization stress. Psychopharmacology (Berl). 2004, 177(1-2):230-7.

Ons S, Martí O, Armario A. Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA. J Neurochem. 2004, 89(5):1111-8.

Márquez C, Nadal R, Armario A. The hypothalamic-pituitary-adrenal and glucose responses to daily repeated immobilisation stress in rats: individual differences. Neuroscience. 2004, 123(3):601-12.

2003

Bertuzzi ML, Bensi N, Mayer N, Niebylski A, Armario A, Gauna HF. Renal mechanisms involved in stress-induced antinatriuresis and antidiuresis in rats. Arch Physiol Biochem. 2003, 111(3):259-64.

Dal-Zotto S, Martí O, Armario A. Glucocorticoids are involved in the long-term effects of a single immobilization stress on the hypothalamic-pituitary-adrenal axis. Psychoneuroendocrinology. 2003, 28(8):992-1009.

Vallès A, Martí O, Armario A. Long-term effects of a single exposure to immobilization stress on the hypothalamic-pituitary-adrenal axis: transcriptional evidence for a progressive desensitization process. Eur J Neurosci. 2003, 18(6):1353-61.

Finn DP, Martí O, Harbuz MS, Vallès A, Belda X, Márquez C, Jessop DS, Lalies MD, Armario A, Nutt DJ, Hudson AL. Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology. 2003, 167(2):195-202.

2002

Rotllant D, Ons S, Carrasco J, Armario A. Evidence that metyrapone can act as a stressor: effect on pituitary-adrenal hormones, plasma glucose and brain c-fos induction. Eur J Neurosci. 2002, 16(4):693-700.

Nadal R, Armario A, Janak PH. Positive relationship between activity in a novel environment and operant ethanol self-administration in rats. Psychopharmacology. 2002, 162(3):333-8.

Vallès A, Martí O, Harbuz MS, Armario A. A single lipopolysaccharide administration is sufficient to induce a long-term desensitization of the hypothalamic-pituitary-adrenal axis. Neuroscience. 2002, 112(2):383-9.

Márquez C, Belda X, Armario A. Post-stress recovery of pituitary-adrenal hormones and glucose, but not the response during exposure to the stressor, is a marker of stress intensity in highly stressful situations. Brain Res. 2002, 926(1-2):181-5.

Dal-Zotto S, Martí O, Armario A. Is repeated exposure to immobilization needed to induce adaptation of the hypothalamic-pituitary-adrenal axis? Influence of adrenal factors. Behav Brain Res. 2002, 129(1-2):187-95.